Promethazine and codeine needs to be utilized during pregnancy only if the likely gain justifies the potential risk to your fetus.
There's no common agreement about unique pharmacological treatment method regimens for uncomplicated NMS.
Promethazine is actually a phenothiazine by-product which differs structurally with the antipsychotic phenothiazines because of the existence of a branched facet chain and no ring substitution.
Avoidance and Charge of nausea and vomiting affiliated with specified forms of anesthesia and surgery.
Medical reports of promethazine formulations didn't incorporate adequate figures of subjects aged 65 and more than to ascertain whether they answer in different ways from younger topics. Other noted scientific practical experience hasn't recognized variations in responses amongst the elderly and more youthful people.
Prescription drug abuse could be the intentional non-therapeutic utilization of a prescription drug, even once, for its rewarding psychological or physiological consequences.
Promethazine HCl and Codeine Phosphate Oral Answer must be employed with caution in sufferers with bone- marrow despair. Leukopenia and agranulocytosis are actually reported, commonly when promethazine has actually been Employed in Affiliation with other regarded marrow-harmful agents.
Promethazine HCl Oral Alternative could impair the mental and/or Bodily talents needed with the performance of probably dangerous tasks, including driving a car or working machinery. The impairment can be amplified by concomitant use of other central-nervous-method depressants for instance Alcoholic beverages, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, standard anesthetics, tricyclic antidepressants, and tranquilizers; thus these types of agents must either be removed or offered in lessened dosage while in the presence of promethazine HCl (see Safeguards – Data for People and Drug Interactions).
Promethazine HCl Oral Alternative may possibly reduce seizure threshold. It should be utilised with warning in persons with seizure Issues or in people who will be applying concomitant remedies, which include narcotics or area anesthetics, which can also affect seizure threshold.
Promethazine HCl occurs as a white to faint yellow, pretty much odorless, crystalline powder which bit by bit oxidizes and turns blue on prolonged publicity to air. It's freely soluble get more info in drinking water and soluble in alcohol.
Concomitant administration of Promethazine products with other respiratory depressants has an association with respiratory depression, and at times Loss of life, in pediatric sufferers.
Contact area state professional licensing board or condition managed substances authority for information on how to stop and detect abuse or diversion of this product.
The phosphate salt of codeine occurs as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and slightly soluble in Alcoholic beverages.
Put the mixture within a container like a sealed plastic bag and toss it away inside the household trash. It's also possible to comply with your point out or community suggestions on how to safely and securely toss away Promethazine Hydrochloride and Codeine Phosphate Oral Alternative.